Clinical Data Standardization

Clinical data on cases enrolled in major NCI CCG programs are provided by Biospecimen Core Repositories (BCRs) in schema-valid XML format. Other submitters may provide clinical data in a tab-delimited text or json format via a GDC web page. Clinical data elements indexed by the GDC are described in the following table.

More information about each of the clinical elements, including their descriptions and value domains, can be found in the GDC Data Dictionary Viewer. The links for each clinical entity dictionary entry are listed below:

Clinical Data Table

Term Category CDE Required?
aa change Molecular test 6142508 No
additional pathology findings Pathology detail --- No
adrenal hormone Diagnosis C2264 No
adverse event grade Follow up 2944515 No
adverse event Follow up 3125302 No
age at diagnosis Diagnosis 3225640 Yes
age at index Demographic 6028530 No
age at last exposure Exposure --- No
age at onset Exposure --- No
age is obfuscated Demographic --- No
aids risk factors Follow up --- No
ajcc clinical m Diagnosis 3440331 No
ajcc clinical n Diagnosis 3440330 No
ajcc clinical stage Diagnosis 3440332 No
ajcc clinical t Diagnosis 3440328 No
ajcc pathologic m Diagnosis 3045439 No
ajcc pathologic n Diagnosis 3203106 No
ajcc pathologic stage Diagnosis 3203222 No
ajcc pathologic t Diagnosis 3045435 No
ajcc staging system edition Diagnosis 2722309 No
alcohol days per week Exposure 3114013 No
alcohol drinks per day Exposure 3124961 No
alcohol history Exposure 2201918 No
alcohol intensity Exposure 3457767 No
alcohol type Exposure --- No
anaplasia present type Pathology detail 4925534 No
anaplasia present Pathology detail 6059599 No
ann arbor b symptoms described Diagnosis --- No
ann arbor b symptoms Diagnosis 2902402 No
ann arbor clinical stage Diagnosis 5615604 No
ann arbor extranodal involvement Diagnosis 3364582 No
ann arbor pathologic stage Diagnosis 5615605 No
antigen Molecular test 6142523 No
asbestos exposure type Exposure --- No
asbestos exposure Exposure 1253 No
barretts esophagus goblet cells present Follow up 3440216 No
best overall response Diagnosis 2003324 No
biospecimen type Molecular test --- No
biospecimen volume Molecular test --- No
blood test normal range lower Molecular test 6142571 No
blood test normal range upper Molecular test 6142535 No
bmi Follow up 2006410 No
body surface area Follow up 653 No
bone marrow malignant cells Pathology detail --- No
breslow thickness Pathology detail 64809 No
burkitt lymphoma clinical variant Diagnosis 3770421 No
cause of death source Demographic --- No
cause of death Demographic 2554674 No
cause of response Follow up 6161025 No
cd4 count Follow up 4182751 No
cdc hiv risk factors Follow up --- No
cell count Molecular test 6142528 No
chemo concurrent to radiation Treatment --- No
child pugh classification Diagnosis 2931791 No
chromosome Molecular test 6142404 No
cigarettes per day Exposure 2001716 No
circumferential resection margin Pathology detail 6161030 No
classification of tumor Diagnosis 3288124 No
clinical trial indicator Treatment --- No
clonality Molecular test --- No
coal dust exposure Exposure --- No
cog liver stage Diagnosis 6013618 No
cog neuroblastoma risk group Diagnosis 4616452 No
cog renal stage Diagnosis 6013641 No
cog rhabdomyosarcoma risk group Diagnosis 6133604 No
columnar mucosa present Pathology detail --- No
comorbidity method of diagnosis Follow up 6142386 No
comorbidity Follow up 2970715 No
consistent pathology review Pathology detail --- No
copy number Molecular test 6142519 No
country of residence at enrollment Demographic 7050286 No
course number Treatment C166235 No
cytoband Molecular test 6142405 No
days to adverse event Follow up 6154728 No
days to best overall response Diagnosis 6154732 No
days to birth Demographic 6154723 No
days to comorbidity Follow up --- No
days to death Demographic 6154724 No
days to diagnosis Diagnosis 6154733 No
days to follow up Follow up 6154727 Yes
days to imaging Follow up --- No
days to last follow up Diagnosis 3008273 No
days to last known disease status Diagnosis 3008273 No
days to progression free Follow up --- No
days to progression Follow up 6154730 No
days to recurrence Diagnosis 6154731 No
days to recurrence Follow up 6154731 No
days to test Molecular test --- No
days to treatment end Treatment 6154725 No
days to treatment start Treatment 6154726 No
diabetes treatment type Follow up 3587247 No
diagnosis is primary disease Diagnosis --- Yes
disease response Follow up 5750671 No
dlco ref predictive percent Follow up 2180255 No
double expressor lymphoma Diagnosis C138900 No
double hit lymphoma Diagnosis C125904 No
drug category Treatment --- No
dysplasia degree Pathology detail --- No
dysplasia type Pathology detail --- No
ecog performance status Follow up 88 No
eln risk classification Diagnosis --- No
embolic agent Treatment C97229 No
enneking msts grade Diagnosis 6003955 No
enneking msts metastasis Diagnosis 6003958 No
enneking msts stage Diagnosis 6060045 No
enneking msts tumor site Diagnosis 6003957 No
environmental tobacco smoke exposure Exposure --- No
esophageal columnar dysplasia degree Diagnosis 3440917 No
esophageal columnar metaplasia present Diagnosis 3440218 No
ethnicity Demographic 2192217 Yes
evidence of recurrence type Follow up --- No
exon Molecular test 6142411 No
exposure duration years Exposure C83280 No
exposure duration Exposure --- No
exposure source Exposure --- No
exposure type Exposure --- No
eye color Follow up C157437 No
fev1 fvc post bronch percent Follow up 3302956 No
fev1 fvc pre bronch percent Follow up 3302955 No
fev1 ref post bronch percent Follow up 3302948 No
fev1 ref pre bronch percent Follow up 3302947 No
figo stage Diagnosis 3225684 No
figo staging edition year Diagnosis --- No
first symptom prior to diagnosis Diagnosis 6133605 No
gastric esophageal junction involvement Diagnosis 6059632 No
gender Demographic 2200604 Yes
gene symbol Molecular test 6142392 Yes
gleason grade group Diagnosis 5918370 No
gleason grade tertiary Diagnosis --- No
gleason patterns percent Diagnosis --- No
goblet cells columnar mucosa present Diagnosis 3440219 No
greatest tumor dimension Pathology detail --- No
gross tumor weight Pathology detail 6133606 No
haart treatment indicator Follow up --- No
height Follow up 649 No
hepatitis sustained virological response Follow up 6423783 No
histone family Molecular test 6142511 No
histone variant Molecular test 6142515 No
history of tumor type Follow up --- No
history of tumor Follow up --- No
hiv viral load Follow up 2649682 No
hormonal contraceptive type Follow up --- No
hormonal contraceptive use Follow up --- No
hormone replacement therapy type Follow up --- No
hpv positive type Follow up 2922649 No
hpv strain Molecular test --- No
hysterectomy margins involved Follow up --- No
hysterectomy type Follow up --- No
icd 10 code Diagnosis 3226287 No
igcccg stage Diagnosis --- No
imaging result Follow up --- No
imaging type Follow up --- No
immunosuppressive treatment type Follow up --- No
initial disease status Treatment --- No
inpc grade Diagnosis 6133602 No
inpc histologic group Diagnosis 4616372 No
inrg stage Diagnosis 5777238 No
inss stage Diagnosis 6133603 No
international prognostic index Diagnosis 2500234 No
intron Molecular test 6514355 No
irs group Diagnosis 6141658 No
irs stage Diagnosis 5162089 No
ishak fibrosis score Diagnosis 3182621 No
iss stage Diagnosis 2465385 No
karnofsky performance status Follow up 2003853 No
laboratory test Molecular test --- No
largest extrapelvic peritoneal focus Pathology detail 6690680 No
last known disease status Diagnosis 5424231 No
laterality Diagnosis 827 No
lesions treated number Treatment --- No
loci abnormal count Molecular test 6074182 No
loci count Molecular test 6074183 No
locus Molecular test C45822 No
lymph node involved site Pathology detail --- No
lymph node involvement Pathology detail --- No
lymph nodes positive Pathology detail 89 No
lymph nodes tested Pathology detail 3 No
lymphatic invasion present Pathology detail 64171 No
margin distance Diagnosis --- No
margin status Pathology detail --- No
margins involved site Diagnosis --- No
masaoka stage Diagnosis 3952848 No
max tumor bulk site Diagnosis --- No
medulloblastoma molecular classification Diagnosis 6002209 No
menopause status Follow up 2434914 No
metaplasia present Pathology detail --- No
metastasis at diagnosis site Diagnosis 3029815 No
metastasis at diagnosis Diagnosis 6133614 No
method of diagnosis Diagnosis 6161031 No
micropapillary features Diagnosis 6068784 No
mismatch repair mutation Molecular test 6142534 No
mitosis karyorrhexis index Diagnosis 4616412 No
mitotic count Diagnosis C47864 No
mitotic count Molecular test C47864 No
mitotic total area Molecular test --- No
molecular analysis method Molecular test 6142401 Yes
molecular consequence Molecular test 6142403 No
morphologic architectural pattern Pathology detail --- No
morphology Diagnosis 3226275 Yes
nadir cd4 count Follow up --- No
necrosis percent Pathology detail --- No
necrosis present Pathology detail --- No
non nodal regional disease Pathology detail --- No
non nodal tumor deposits Pathology detail 3107051 No
number of cycles Treatment --- No
number of fractions Treatment --- No
number proliferating cells Pathology detail 5432636 No
occupation duration years Demographic 2435424 No
ovarian specimen status Diagnosis 6690671 No
ovarian surface involvement Diagnosis 6690674 No
pack years smoked Exposure 2955385 No
pancreatitis onset year Follow up 3457763 No
papillary renal cell type Diagnosis --- No
parent with radiation exposure Exposure --- No
pathogenicity Molecular test --- No
percent tumor invasion Pathology detail --- No
perineural invasion present Pathology detail 64181 No
peripancreatic lymph nodes positive Pathology detail 5983082 No
peripancreatic lymph nodes tested Pathology detail 6050944 No
peritoneal fluid cytological status Diagnosis 6690681 No
ploidy Molecular test 6142527 No
pregnancy outcome Follow up --- No
pregnant at diagnosis Diagnosis --- No
premature at birth Demographic 6010765 No
prescribed dose Treatment --- No
primary diagnosis Diagnosis 6161032 Yes
primary disease Diagnosis --- No
primary gleason grade Diagnosis 5936800 No
prior malignancy Diagnosis 3382736 No
prior treatment Diagnosis 4231463 No
procedures performed Follow up --- No
progression or recurrence anatomic site Follow up 6161026 No
progression or recurrence type Follow up 6142385 No
progression or recurrence Diagnosis 3121376 No
progression or recurrence Follow up 3121376 No
prostatic chips positive count Pathology detail --- No
prostatic chips total count Pathology detail --- No
prostatic involvement percent Pathology detail --- No
protocol identifier Treatment C132299 No
race Demographic 2192199 Yes
radon exposure Exposure 2816352 No
reason treatment ended Treatment --- No
recist targeted regions number Follow up --- No
recist targeted regions sum Follow up --- No
reflux treatment type Follow up 3440206 No
regimen or line of therapy Treatment 6161024 No
relationship age at diagnosis Family history 5300571 No
relationship gender Family history 6161021 No
relationship primary diagnosis Family history 6161022 No
relationship type Family history 2690165 No
relative with cancer history Family history 6161023 No
relatives with cancer history count Family history --- No
residual disease Diagnosis 2608702 No
residual tumor Pathology detail C4809 No
respirable crystalline silica exposure Exposure --- No
rhabdoid percent Pathology detail 6790120 No
rhabdoid present Pathology detail --- No
risk factor treatment Follow up 6514356 No
risk factor Follow up 6142389 No
route of administration Treatment C38114 No
sarcomatoid percent Pathology detail 2429786 No
sarcomatoid present Pathology detail --- No
satellite nodule present Diagnosis --- No
scan tracer used Follow up --- No
second exon Molecular test --- No
second gene symbol Molecular test 6142393 No
secondary gleason grade Diagnosis 5936802 No
secondhand smoke as child Exposure 6841888 No
site of resection or biopsy Diagnosis 6161034 Yes
sites of involvement Diagnosis --- No
size extraocular nodule Pathology detail --- No
smoking frequency Exposure --- No
specialized molecular test Molecular test 6142526 No
supratentorial localization Diagnosis 3133891 No
synchronous malignancy Diagnosis 6142390 No
test analyte type Molecular test 6142394 No
test result Molecular test 6142397 Yes
test units Molecular test 6142525 No
test value Molecular test 6142524 No
therapeutic agents Treatment 2975232 No
time between waking and first smoke Exposure 3279220 No
tissue or organ of origin Diagnosis 6161035 Yes
tobacco smoking onset year Exposure 2228604 No
tobacco smoking quit year Exposure 2228610 No
tobacco smoking status Exposure 2181650 No
transcript Molecular test 6142465 No
transglottic extension Pathology detail --- No
treatment anatomic site Treatment 5615611 No
treatment arm Treatment 7068995 No
treatment dose max Treatment --- No
treatment dose units Treatment --- No
treatment dose Treatment 2182728 No
treatment effect indicator Treatment --- No
treatment effect Treatment 6514354 No
treatment frequency Treatment --- No
treatment intent type Treatment 2793511 No
treatment or therapy Treatment 4231463 No
treatment outcome Treatment 5102383 No
treatment type Treatment 5102381 No
tumor confined to organ of origin Diagnosis 4925494 No
tumor depth Diagnosis --- No
tumor focality Diagnosis 3174022 No
tumor grade Diagnosis 2785839 No
tumor largest dimension diameter Pathology detail 64215 No
tumor level prostate Pathology detail --- No
tumor regression grade Diagnosis 6471217 No
tumor thickness Pathology detail C176286 No
type of smoke exposure Exposure --- No
type of tobacco used Exposure --- No
uicc clinical m Diagnosis --- No
uicc clinical n Diagnosis --- No
uicc clinical stage Diagnosis --- No
uicc clinical t Diagnosis --- No
uicc pathologic m Diagnosis --- No
uicc pathologic n Diagnosis --- No
uicc pathologic stage Diagnosis --- No
uicc pathologic t Diagnosis --- No
undescended testis corrected age Follow up --- No
undescended testis corrected laterality Follow up --- No
undescended testis corrected method Follow up --- No
undescended testis corrected Follow up --- No
undescended testis history laterality Follow up --- No
undescended testis history Follow up C12326 No
use per day Exposure --- No
variant origin Molecular test --- No
variant type Molecular test 6142402 No
vascular invasion present Pathology detail 64358 No
vascular invasion type Pathology detail 3168001 No
viral hepatitis serologies Follow up 4395982 No
vital status Demographic 5 Yes
weeks gestation at birth Demographic 2737369 No
weight Follow up 651 No
weiss assessment score Diagnosis 3648744 No
who cns grade Diagnosis --- No
who nte grade Diagnosis --- No
wilms tumor histologic subtype Diagnosis 4358735 No
year of birth Demographic 2896954 No
year of death Demographic 2897030 No
year of diagnosis Diagnosis 2896960 No
years smoked Exposure 3137957 No
zone of origin prostate Pathology detail --- No
zygosity Molecular test 6142510 No