Clinical Data Harmonization

Clinical data on cases enrolled in major NCI CCG programs are provided by Biospecimen Core Repositories (BCRs) in schema-valid XML format. Other submitters may provide clinical data in a tab-delimited text or json format via a GDC web page. Clinical data elements indexed by the GDC are described in the following table.

More information about each of the clinical elements, including their descriptions and value domains, can be found in the GDC Data Dictionary Viewer. The links for each clinical entity dictionary entry are listed below:

Clinical Data Table

Term Category CDE Required / Preferred / Optional
AA Change Molecular Test 6142508 Optional
AJCC Clinical M Diagnosis 3440331 Optional
AJCC Clinical N Diagnosis 3440330 Optional
AJCC Clinical Stage Diagnosis 3440332 Optional
AJCC Clinical T Diagnosis 3440328 Optional
AJCC Pathologic M Diagnosis 3045439 Optional
AJCC Pathologic N Diagnosis 3203106 Optional
AJCC Pathologic Stage Diagnosis 3203222 Optional
AJCC Pathologic T Diagnosis 3045435 Optional
AJCC Staging System Edition Diagnosis 2722309 Optional
Adverse Event Follow Up 3125302 Optional
Age at Diagnosis Diagnosis 3225640 Required
Age at Index Demographic 6028530 Optional
Alcohol Days per Week Exposure 3114013 Optional
Alcohol Drinks per Day Exposure 3124961 Optional
Alcohol History Exposure 2201918 Optional
Alcohol Intensity Exposure 3457767 Optional
Anaplasia Present Type Diagnosis 4925534 Optional
Anaplasia Present Diagnosis 6059599 Optional
Ann Arbor B Symptoms Diagnosis 2902402 Optional
Ann Arbor Clinical Stage Diagnosis 5615604 Optional
Ann Arbor Extranodal Involvement Diagnosis 3364582 Optional
Ann Arbor Pathologic Stage Diagnosis 5615605 Optional
Antigen Molecular Test 6142523 Optional
BMI Exposure 2006410 Optional
BMI Follow Up 2006410 Optional
Barretts Esophagus Goblet Cells Present Follow Up 3440216 Optional
Best Overall Response Diagnosis 2003324 Optional
Blood Test Normal Range Lower Molecular Test 6142571 Optional
Blood Test Normal Range Upper Molecular Test 6142535 Optional
Blood Test Molecular Test 6142767 Optional
Burkitt Lymphoma Clinical Variant Diagnosis 3770421 Optional
COG Liver Stage Diagnosis 6013618 Optional
COG Neuroblastoma Risk Group Diagnosis 4616452 Optional
COG Renal Stage Diagnosis 6013641 Optional
COG Rhabdomyosarcoma Risk Group Diagnosis 6133604 Optional
Cause of Death Demographic 2554674 Optional
Cause of Death Diagnosis 2554674 Optional
Cause of Response Follow Up -- Optional
Cell Count Molecular Test 6142528 Optional
Child-Pugh Classification Diagnosis 2931791 Optional
Chromosome Molecular Test 6142404 Optional
Cigarettes per Day Exposure 2001716 Optional
Circumferential Resection Margin Diagnosis 64202 Optional
Classification of Tumor Diagnosis 3288124 Optional
Colon Polyps History Diagnosis 3107197 Optional
Comorbidity Method of Diagnosis Follow Up 6142386 Optional
Comorbidity Follow Up 2970715 Optional
Copy Number Molecular Test 6142519 Optional
Cytoband Molecular Test 6142405 Optional
DLCO Ref Predictive Percent Follow Up 2180255 Optional
DNA Change Molecular Test 6142507 Optional
Days to Adverse Event Follow Up -- Optional
Days to Best Overall Response Diagnosis -- Optional
Days to Birth Demographic 3008233 Preferred
Days to Birth Diagnosis 3008233 Optional
Days to Comorbidity Follow Up -- Optional
Days to Death Demographic 3165475 Optional
Days to Death Diagnosis 3165475 Optional
Days to Diagnosis Diagnosis -- Optional
Days to Follow Up Follow Up -- Required
Days to HIV Diagnosis Diagnosis 4618491 Optional
Days to Last Follow Up Diagnosis 3008273 Required
Days to Last Known Disease Status Diagnosis 3008273 Required
Days to New Event Diagnosis 3392464 Optional
Days to Progression Follow Up -- Optional
Days to Recurrence Diagnosis -- Required
Days to Recurrence Follow Up -- Optional
Days to Treatment End Treatment 5102431 Optional
Days to Treatment Start Treatment 5102411 Optional
Diabetes Treatment Type Follow Up 3587247 Optional
Disease Response Follow Up -- Optional
ECOG Performance Status Follow Up 88 Optional
Enneking MSTS Grade Diagnosis 6003955 Optional
Enneking MSTS Metastasis Diagnosis 6003958 Optional
Enneking MSTS Stage Diagnosis 6060045 Optional
Enneking MSTS Tumor Site Diagnosis 6003957 Optional
Esophageal Columnar Dysplasia Degree Diagnosis 3440917 Optional
Esophageal Columnar Metaplasia Present Diagnosis 3440218 Optional
Ethnicity Demographic 2192217 Required
Exon Molecular Test 6142411 Optional
FEV1 FVC Post Bronch Percent Follow Up 3302956 Optional
FEV1 FVC Pre Bronch Percent Follow Up 3302955 Optional
FEV1 Ref Post Bronch Percent Follow Up 3302948 Optional
FEV1 Ref Pre Bronch Percent Follow Up 3302947 Optional
FIGO Stage Diagnosis 3225684 Optional
First Symptom Prior to Diagnosis Diagnosis 6133605 Optional
Gastric Esophageal Junction Involvement Diagnosis 6059632 Optional
Gender Demographic 2200604 Required
Gene Symbol Molecular Test 6142392 Required
Goblet Cells Columnar Mucosa Present Diagnosis 3440219 Optional
Gross Tumor Weight Diagnosis 6133606 Optional
HIV Positive Diagnosis 4030799 Optional
HPV Positive Type Diagnosis 2922649 Optional
HPV Positive Type Follow Up 2922649 Optional
HPV Status Diagnosis 2230033 Optional
Height Exposure 649 Optional
Height Follow Up 649 Optional
Histone Family Molecular Test 6142511 Optional
Histone Variant Molecular Test 6142515 Optional
ICD 10 Code Diagnosis 3226287 Optional
INPC Grade Diagnosis 6133602 Optional
INPC Histologic Group Diagnosis 4616372 Optional
INRG Stage Diagnosis 5777238 Optional
INSS Stage Diagnosis 6133603 Optional
IRS Group Diagnosis 6141658 Optional
IRS Stage Diagnosis 5162089 Optional
ISS Stage Diagnosis 2465385 Optional
Ishak Fibrosis Score Diagnosis 3182621 Optional
Karnofsky Performance Status Follow Up 2003853 Optional
LDH Level at Diagnosis Diagnosis 2798766 Optional
LDH Normal Range Upper Diagnosis 2597015 Optional
Last Known Disease Status Diagnosis 5424231 Required
Laterality Diagnosis 827 Optional
Loci Abnormal Count Molecular Test 6074182 Optional
Loci Count Molecular Test 6074183 Optional
Locus Molecular Test 6142506 Optional
Lymph Nodes Positive Diagnosis 89 Optional
Lymphatic Invasion Present Diagnosis 64171 Optional
Medulloblastoma Molecular Classification Diagnosis 6002209 Optional
Menopause Status Follow Up 2434914 Optional
Metastasis at Diagnosis Site Diagnosis 3029815 Optional
Metastasis at Diagnosis Diagnosis 6133614 Optional
Method of Diagnosis Diagnosis -- Optional
Micropapillary Features Diagnosis 6068784 Optional
Mismatch Repair Mutation Molecular Test 6142534 Optional
Mitosis Karyorrhexis Index Diagnosis 4616412 Optional
Molecular Analysis Method Molecular Test 6142401 Required
Molecular Consequence Molecular Test 6142403 Optional
Morphology Diagnosis 3226275 Required
New Event Anatomic Site Diagnosis 3108271 Optional
New Event Type Diagnosis 3119721 Optional
Overall Survival Diagnosis -- Optional
Pack Years Smoked Exposure 2955385 Preferred
Pancreatitis Onset Year Follow Up 3457763 Optional
Perineural Invasion Present Diagnosis 64181 Optional
Peripancreatic Lymph Nodes Positive Diagnosis 5983082 Optional
Peripancreatic Lymph Nodes Tested Diagnosis 6050944 Optional
Ploidy Molecular Test 6142527 Optional
Premature at Birth Demographic 6010765 Optional
Primary Diagnosis Diagnosis 3081934 Required
Prior Malignancy Diagnosis 3382736 Optional
Prior Treatment Diagnosis 4231463 Optional
Progression Free Survival Event Diagnosis -- Optional
Progression Free Survival Diagnosis -- Optional
Progression or Recurrence Anatomic Site Follow Up -- Optional
Progression or Recurrence Type Follow Up 6142385 Optional
Progression or Recurrence Diagnosis 3121376 Required
Progression or Recurrence Follow Up 3121376 Optional
RNA Change Molecular Test 6142509 Optional
Race Demographic 2192199 Required
Reflux Treatment Type Follow Up 3440206 Optional
Reflux Treatment Follow Up 6133607 Optional
Regimen or Line of Therapy Treatment -- Optional
Relationship Age at Diagnosis Family History 5300571 Optional
Relationship Gender Family History 2200604 Optional
Relationship Primary Diagnosis Family History 3081934 Optional
Relationship Type Family History 2690165 Optional
Relative with Cancer History Family History 3901752 Optional
Residual Disease Diagnosis 2608702 Optional
Risk Factor Follow Up 6142389 Optional
Second Gene Symbol Molecular Test 6142393 Optional
Site of Resection or Biopsy Diagnosis 3226281 Required
Specialized Molecular Test Molecular Test 6142526 Optional
Supratentorial Localization Diagnosis 3133891 Optional
Synchronous Malignancy Diagnosis 6142390 Optional
Test Analyte Type Molecular Test 6142394 Optional
Test Result Molecular Test 6142397 Required
Test Units Molecular Test 6142525 Optional
Test Value Molecular Test 6142524 Optional
Therapeutic Agents Treatment 2975232 Optional
Tissue or Organ of Origin Diagnosis 3427536 Required
Tobacco Smoking Onset Year Exposure 2228604 Optional
Tobacco Smoking Quit Year Exposure 2228610 Optional
Tobacco Smoking Status Exposure 2181650 Optional
Transcript Molecular Test 6142465 Optional
Treatment Anatomic Site Treatment 5615611 Optional
Treatment Intent Type Treatment 2793511 Optional
Treatment Outcome Treatment 5102383 Optional
Treatment Type Treatment 5102381 Optional
Treatment or Therapy Treatment 4231463 Optional
Tumor Confined to Organ of Origin Diagnosis 4925494 Optional
Tumor Grade Diagnosis 2785839 Required
Tumor Largest Dimension Diameter Diagnosis 64215 Optional
Tumor Stage Diagnosis C16899 Required
Variant Type Molecular Test 6142402 Optional
Vascular Invasion Present Diagnosis 64358 Optional
Vascular Invasion Type Diagnosis 3168001 Optional
Viral Hepatitis Serologies Follow Up 4395982 Optional
Vital Status Demographic 5 Optional
Vital Status Diagnosis 5 Required
Weeks Gestation at Birth Demographic 2737369 Optional
Weight Exposure 651 Optional
Weight Follow Up 651 Optional
Wilms Tumor Histologic Subtype Diagnosis 4358735 Optional
Year of Birth Demographic 2896954 Optional
Year of Death Demographic 2897030 Preferred
Year of diagnosis Diagnosis 2896960 Optional
Years Smoked Exposure 3137957 Preferred
Zygosity Molecular Test 6142510 Optional