Clinical Data Harmonization

Clinical data on cases enrolled in major NCI CCG programs are provided by Biospecimen Core Repositories (BCRs) in schema-valid XML format. Other submitters may provide clinical data in a tab-delimited text or json format via a GDC web page. Clinical data elements indexed by the GDC are described in the following table.

More information about each of the clinical elements, including their descriptions and value domains, can be found in the GDC Data Dictionary Viewer. The links for each clinical entity dictionary entry are listed below:

Clinical Data Table

Term Category CDE Required / Preferred / Optional
AA Change Molecular Test 6142508 Optional
AJCC Clinical M Diagnosis 3440331 Optional
AJCC Clinical N Diagnosis 3440330 Optional
AJCC Clinical Stage Diagnosis 3440332 Optional
AJCC Clinical T Diagnosis 3440328 Optional
AJCC Pathologic M Diagnosis 3045439 Optional
AJCC Pathologic N Diagnosis 3203106 Optional
AJCC Pathologic Stage Diagnosis 3203222 Optional
AJCC Pathologic T Diagnosis 3045435 Optional
AJCC Staging System Edition Diagnosis 2722309 Optional
Adverse Event Follow Up 3125302 Optional
Age at Diagnosis Diagnosis 3225640 Required
Age at Index Demographic 6028530 Optional
Age is Obfuscated Demographic --- Optional
Alcohol Days per Week Exposure 3114013 Optional
Alcohol Drinks per Day Exposure 3124961 Optional
Alcohol History Exposure 2201918 Optional
Alcohol Intensity Exposure 3457767 Optional
Anaplasia Present Type Diagnosis 4925534 Optional
Anaplasia Present Diagnosis 6059599 Optional
Ann Arbor B Symptoms Diagnosis 2902402 Optional
Ann Arbor Clinical Stage Diagnosis 5615604 Optional
Ann Arbor Extranodal Involvement Diagnosis 3364582 Optional
Ann Arbor Pathologic Stage Diagnosis 5615605 Optional
Antigen Molecular Test 6142523 Optional
Asbestos Exposure Exposure 1253 Optional
BMI Exposure 2006410 Optional
BMI Follow Up 2006410 Optional
Barretts Esophagus Goblet Cells Present Follow Up 3440216 Optional
Best Overall Response Diagnosis 2003324 Optional
Biospecimen Type Molecular Test --- Optional
Blood Test Normal Range Lower Molecular Test 6142571 Optional
Blood Test Normal Range Upper Molecular Test 6142535 Optional
Breslow Thickness Diagnosis 64809 Optional
Burkitt Lymphoma Clinical Variant Diagnosis 3770421 Optional
COG Liver Stage Diagnosis 6013618 Optional
COG Neuroblastoma Risk Group Diagnosis 4616452 Optional
COG Renal Stage Diagnosis 6013641 Optional
COG Rhabdomyosarcoma Risk Group Diagnosis 6133604 Optional
Cause of Death Source Demographic --- Optional
Cause of Death Demographic 2554674 Optional
Cause of Response Follow Up 6161025 Optional
Cell Count Molecular Test 6142528 Optional
Child Pugh Classification Diagnosis 2931791 Optional
Chromosome Molecular Test 6142404 Optional
Cigarettes per Day Exposure 2001716 Optional
Circumferential Resection Margin Diagnosis 6161030 Optional
Classification of Tumor Diagnosis 3288124 Optional
Coal Dust Exposure Exposure --- Optional
Comorbidity Method of Diagnosis Follow Up 6142386 Optional
Comorbidity Follow Up 2970715 Optional
Copy Number Molecular Test 6142519 Optional
Cytoband Molecular Test 6142405 Optional
DLCO Ref Predictive Percent Follow Up 2180255 Optional
Days to Adverse Event Follow Up 6154728 Optional
Days to Best Overall Response Diagnosis 6154732 Optional
Days to Birth Demographic 6154723 Preferred
Days to Comorbidity Follow Up 6154729 Optional
Days to Death Demographic 6154724 Optional
Days to Diagnosis Diagnosis 6154733 Optional
Days to Follow Up Follow Up 6154727 Required
Days to Last Follow Up Diagnosis 3008273 Required
Days to Last Known Disease Status Diagnosis 3008273 Required
Days to Progression Free Follow Up --- Optional
Days to Progression Follow Up 6154730 Optional
Days to Recurrence Diagnosis 6154731 Required
Days to Recurrence Follow Up 6154731 Optional
Days to Treatment end Treatment 6154725 Optional
Days to Treatment start Treatment 6154726 Optional
Diabetes Treatment type Follow Up 3587247 Optional
Disease Response Follow Up 5750671 Optional
ECOG Performance Status Follow Up 88 Optional
Enneking MSTS Grade Diagnosis 6003955 Optional
Enneking MSTS Metastasis Diagnosis 6003958 Optional
Enneking MSTS Stage Diagnosis 6060045 Optional
Enneking MSTS Tumor Site Diagnosis 6003957 Optional
Environmental Tobacco Smoke Exposure Exposure --- Optional
Esophageal Columnar Dysplasia Degree Diagnosis 3440917 Optional
Esophageal Columnar Metaplasia Present Diagnosis 3440218 Optional
Ethnicity Demographic 2192217 Required
Exon Molecular Test 6142411 Optional
FEV1 FVC Post Bronch Percent Follow Up 3302956 Optional
FEV1 FVC Pre Bronch Percent Follow Up 3302955 Optional
FEV1 Ref Post Bronch Percent Follow Up 3302948 Optional
FEV1 Ref Pre Bronch Percent Follow Up 3302947 Optional
FIGO Stage Diagnosis 3225684 Optional
First Symptom Prior to Diagnosis Diagnosis 6133605 Optional
Gastric Esophageal Junction Involvement Diagnosis 6059632 Optional
Gender Demographic 2200604 Required
Gene Symbol Molecular Test 6142392 Required
Gleason Grade Group Diagnosis 5918370 Optional
Goblet Cells Columnar Mucosa Present Diagnosis 3440219 Optional
Gross Tumor Weight Diagnosis 6133606 Optional
HPV Positive Type Follow Up 2922649 Optional
Height Exposure 649 Optional
Height Follow Up 649 Optional
Hepatitis Sustained Virological Response Follow Up 6423783 Optional
Histone Family Molecular Test 6142511 Optional
Histone Variant Molecular Test 6142515 Optional
ICD 10 Code Diagnosis 3226287 Optional
IGCCCG Stage Diagnosis --- Optional
INPC Grade Diagnosis 6133602 Optional
INPC Histologic Group Diagnosis 4616372 Optional
INRG Stage Diagnosis 5777238 Optional
INSS Stage Diagnosis 6133603 Optional
IRS Group Diagnosis 6141658 Optional
IRS Stage Diagnosis 5162089 Optional
ISS Stage Diagnosis 2465385 Optional
Initial Disease status Treatment --- Optional
International Prognostic Index Diagnosis 2500234 Optional
Intron Molecular Test 6514355 Optional
Ishak Fibrosis Score Diagnosis 3182621 Optional
Karnofsky Performance Status Follow Up 2003853 Optional
Laboratory Test Molecular Test --- Optional
Largest Extrapelvic Peritoneal Focus Diagnosis 6690680 Optional
Last Known Disease Status Diagnosis 5424231 Required
Laterality Diagnosis 827 Optional
Loci Abnormal Count Molecular Test 6074182 Optional
Loci Count Molecular Test 6074183 Optional
Locus Molecular Test 6142506 Optional
Lymph Nodes Positive Diagnosis 89 Optional
Lymph Nodes Tested Diagnosis 3 Optional
Lymphatic Invasion Present Diagnosis 64171 Optional
Masaoka Stage Diagnosis 3952848 Optional
Medulloblastoma Molecular Classification Diagnosis 6002209 Optional
Menopause Status Follow Up 2434914 Optional
Metastasis at Diagnosis Site Diagnosis 3029815 Optional
Metastasis at Diagnosis Diagnosis 6133614 Optional
Method of Diagnosis Diagnosis 6161031 Optional
Micropapillary Features Diagnosis 6068784 Optional
Mismatch Repair Mutation Molecular Test 6142534 Optional
Mitosis Karyorrhexis Index Diagnosis 4616412 Optional
Mitotic Count Diagnosis --- Optional
Molecular Analysis Method Molecular Test 6142401 Required
Molecular Consequence Molecular Test 6142403 Optional
Morphology Diagnosis 3226275 Required
Non Nodal Regional Disease Diagnosis --- Optional
Non Nodal Tumor Deposits Diagnosis 3107051 Optional
Occupation Duration Years Demographic 2435424 Optional
Ovarian Specimen Status Diagnosis 6690671 Optional
Ovarian Surface Involvement Diagnosis 6690674 Optional
Pack Years Smoked Exposure 2955385 Preferred
Pancreatitis Onset Year Follow Up 3457763 Optional
Pathogenicity Molecular Test --- Optional
Percent Tumor Invasion Diagnosis --- Optional
Perineural Invasion Present Diagnosis 64181 Optional
Peripancreatic Lymph Nodes Positive Diagnosis 5983082 Optional
Peripancreatic Lymph Nodes Tested Diagnosis 6050944 Optional
Peritoneal Fluid Cytological Status Diagnosis 6690681 Optional
Ploidy Molecular Test 6142527 Optional
Premature at Birth Demographic 6010765 Optional
Primary Diagnosis Diagnosis 6161032 Required
Primary Gleason Grade Diagnosis 5936800 Optional
Prior Malignancy Diagnosis 3382736 Optional
Prior Treatment Diagnosis 4231463 Optional
Progression or Recurrence Anatomic Site Follow Up 6161026 Optional
Progression or Recurrence Type Follow Up 6142385 Optional
Progression or Recurrence Diagnosis 3121376 Required
Progression or Recurrence Follow Up 3121376 Optional
Race Demographic 2192199 Required
Radon Exposure Exposure 2816352 Optional
Reflux Treatment Type Follow Up 3440206 Optional
Regimen or Line of Therapy Treatment 6161024 Optional
Relationship Age at Diagnosis Family History 5300571 Optional
Relationship Gender Family History 6161021 Optional
Relationship Primary Diagnosis Family History 6161022 Optional
Relationship Type Family History 2690165 Optional
Relative with Cancer History Family History 6161023 Optional
Relatives with Cancer History Count Family History --- Optional
Residual Disease Diagnosis 2608702 Optional
Respirable Crystalline Silica Exposure Exposure --- Optional
Risk Factor Treatment Follow Up 6514356 Optional
Risk Factor Follow Up 6142389 Optional
Second Exon Molecular Test --- Optional
Second Gene Symbol Molecular Test 6142393 Optional
Secondary Gleason Grade Diagnosis 5936802 Optional
Site of Resection or Biopsy Diagnosis 6161034 Required
Smoking Frequency Exposure --- Optional
Specialized Molecular Test Molecular Test 6142526 Optional
Supratentorial Localization Diagnosis 3133891 Optional
Synchronous Malignancy Diagnosis 6142390 Optional
Test Analyte Type Molecular Test 6142394 Optional
Test Result Molecular Test 6142397 Required
Test Units Molecular Test 6142525 Optional
Test Value Molecular Test 6142524 Optional
Therapeutic Agents Treatment 2975232 Optional
Time Between Waking and First Smoke Exposure 3279220 Optional
Tissue or Organ of Origin Diagnosis 6161035 Required
Tobacco Smoking Onset Year Exposure 2228604 Optional
Tobacco Smoking Quit Year Exposure 2228610 Optional
Tobacco Smoking Status Exposure 2181650 Optional
Transcript Molecular Test 6142465 Optional
Treatment Anatomic site Treatment 5615611 Optional
Treatment Effect Treatment 6514354 Optional
Treatment Intent Type Treatment 2793511 Optional
Treatment Outcome Treatment 5102383 Optional
Treatment Type Treatment 5102381 Optional
Treatment or Therapy Treatment 4231463 Optional
Tumor Confined to Organ of Origin Diagnosis 4925494 Optional
Tumor Focality Diagnosis 3174022 Optional
Tumor Grade Diagnosis 2785839 Required
Tumor Largest Dimension Diameter Diagnosis 64215 Optional
Tumor Regression Grade Diagnosis 6471217 Optional
Tumor Stage Diagnosis C16899 Optional
Type of Smoke Exposure Exposure --- Optional
Type of Tobacco Used Exposure --- Optional
Variant Origin Molecular Test --- Optional
Variant Type Molecular Test 6142402 Optional
Vascular Invasion Present Diagnosis 64358 Optional
Vascular Invasion type Diagnosis 3168001 Optional
Viral Hepatitis Serologies Follow Up 4395982 Optional
Vital Status Demographic 5 Required
Weeks Gestation at Birth Demographic 2737369 Optional
Weight Exposure 651 Optional
Weight Follow Up 651 Optional
Weiss Assessment Score Diagnosis 3648744 Optional
Wilms Tumor Histologic Subtype Diagnosis 4358735 Optional
Year of Birth Demographic 2896954 Optional
Year of Death Demographic 2897030 Preferred
Year of Diagnosis Diagnosis 2896960 Optional
Years Smoked Exposure 3137957 Preferred
Zygosity Molecular Test 6142510 Optional