There are multiple reasons that could contribute to an instance in which harmonized tumor and normal BAM files for a specific case are available but the variant calls are not. The two most common reasons are as follows:

The GDC is planning Data Release 47 in December 2026, bringing new genomic and clinical datasets to support cancer research. Highlights of the planned release include:

The NCI Office of Data Sharing (ODS) Impact Prize is a competition designed to identify and recognize innovative ideas and successful strategies that advance the broad, rapid, and

The GDC has released Data Release 46, bringing new genomic and clinical datasets to support cancer research. Highlights of this release include:

The GDC released survival analysis and other enhancements in the Xanthopoulos release.

The GDC categorizes whole genome sequencing (WGS) coverage using the wgs_coverage property, which groups BAM files into four range buckets: 0x-10x, 10x-25x, 25x-150x, and 150x+. "High coverage" WGS in the GDC generally refers to alignments with a mean depth of 25x or greater — meaning, on average, each base in the genome is covered by at least 25 sequencing reads. This threshold reflects the minimum depth at which variant calling pipelines (SNV, indel, and structural variant) achieve reliable sensitivity and specificity for somatic mutation detection in cancer genomics.