The National Cancer Institute is establishing the NCI Genomic Data Commons (GDC) to store, analyze and distribute cancer genomics data generated by NCI and other research organizations.
The GDC provides helpdesk support for data submission and other issues. For information on the GDC helpdesk, please visit GDC Support.
Generally, browsing indexed GDC metadata (such as information about the cases and files contained in the GDC Data Portal) does not require a login.
eRA Commons authentication and dbGaP authorization are required before accessing controlled data, which generally includes individually identifiable information such as low level genomic sequencing data and germline variants.
Controlled-access data users log in to the GDC using their eRA Commons accounts. The GDC then verifies that the user has authorization in dbGaP to access specific controlled datasets.
The GDC generates high level data for germline and somatic genotyping, RNA-Seq quantification and structural analysis, SNP Array Genotyping and CNV Calls, and variant annotations. Please visit GDC Data Harmonization for additional information on the GDC high level data generation pipelines.
The GDC is harmonized against GRCh38. Please see GDC Data Harmonization for additional information on the GDC pipelines for re-aligning genomic data.
Please credit the NCI Genomic Data Commons (GDC) in your manuscript by citing the following paper about the GDC in your manuscript:
Heath, A.P., Ferretti, V., Agrawal, S. et al. The NCI Genomic Data Commons. Nat Genet 53, 257-262 (2021). https://doi.org/10.1038/s41588-021-00791-5
When citing individual projects, please refer to the attribution policies of the project when available.
GDC open-access data can be used in publications or presentations with proper accreditation. Use of controlled-access data requires dbGaP access and users must abide by the data use agreement (DUA) associated with the study. See GDC Data Access and Sharing Policies or contact the NCI Office of Data Sharing directly for further clarification: NCIOfficeofDataSharing@mail.nih.gov.
The GDC welcomes collaborations with organizations conducting research in or providing informatics supporting cancer genomics. Organizations interested in collaborating with the GDC should contact GDC Support.
The primary goal of the GDC is to provide the cancer research community with a unified repository and cancer knowledge base supporting cancer genomic studies. The cancer knowledge base enables the identification of low-frequency cancer drivers, assists in defining genomic determinants of response to therapy, and informs the composition of clinical trial cohorts sharing targeted genetic lesions.
The NCI Genomic Data Commons (GDC) is the next generation repository and cancer knowledge base supporting the import and standardization of genomic and clinical data from cancer research programs (e.g. TCGA, TARGET, CGCI), the harmonization of sequence data to the genome / transcriptome, and the application of state-of-the art methods for derived data (e.g. mutation calls, structural variants, etc.).
