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GDC DNA-Seq Data Processing

Date: Monday, September 28, 2020
Time: 2:00 PM - 3:00 PM EDT
Location: Web Conference (See WebEx information below)
Dr. Bill Wysocki, Director of User Services, University of Chicago (UChicago)
Dr. Kyle Hernandez, Research Assistant Professor, University of Chicago (UChicago)

This webinar describes the GDC’s bioinformatics pipelines for identifying somatic variants from whole exome sequencing (WXS) and whole genome sequencing (WGS) data. Experts explain in detail workflows for WXS and WGS data, including comparing normal and tumor samples, filtering, annotating, and aggregating mutations from different callers and cases.

Intended Audience

This webinar is intended for cancer researchers and bioinformaticians who are interested in learning more about the NCI Genomic Data Commons (GDC) bioinformatics pipelines supporting data harmonization.


The GDC DNA-Seq analysis pipeline identifies somatic variants within whole exome sequencing (WXS) and whole genome sequencing (WGS) data. Somatic variants are identified by comparing allele frequencies in normal and tumor sample alignments, annotating each mutation, and aggregating mutations from multiple cases. This webinar will provide an in depth look at how DNA-Seq data is processed at the GDC and made available to the research community.

Included Topics
  • Provide an overview of the GDC DNA-Seq alignment workflows
  • Review the GDC WXS somatic variant calling workflow
  • Review the GDC WGS somatic variant calling, copy number variation, and structural variation workflows
  • Demonstrate download of DNA-Seq data generated from GDC workflows
Webex Information

GDC Webinar: GDC DNA-Seq Data Processing

  • Monday, September 28, 2020
  • 2:00 pm    |    Eastern Standard Time (New York, GMT-04:00)    |    1 hr
  • Meeting number (access code): 172 338 4441
  • Meeting password: KPcfT6vG$25


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