The Multiple Myeloma Research Foundation (MMRF)

Multiple Myeloma Research Foundation (MMRF)

The Multiple Myeloma Research Foundation (MMRF) is a 501(c)(3) non-profit organization established in 1998. The group’s mission is to find a cure for multiple myeloma by pursuing innovation that accelerates the development of next-generation treatments to extend the lives of patients.

The MMRF is focused on using precision medicine to help patients get the right treatment based on their specific molecular information. The MMRF gathers, generates and analyzes vital information about multiple myeloma, patients, and treatments, shares the data with researchers and institutions, and evaluates new treatments through a collaborative research consortium. These efforts are helping to accelerate discovery and produce better, more targeted treatments for people living with multiple myeloma.

Program Description

The Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile study (CoMMpassSM, NCT01454297) is the MMRF’s landmark personalized medicine initiative. CoMMpass is a longitudinal observation study of around 1000 newly diagnosed myeloma patients receiving various standard approved treatments.

The MMRF’s vision is to track the treatment and results for each CoMMpass patient so that someday the information can be used to guide decisions for newly diagnosed patients. CoMMpass checked on patients every 6 months for 8 years, collecting tissue samples, genetic information, quality of life and various disease and clinical outcomes. The study has produced one of the largest genomic and clinical datasets of a single disease.

Data Overview

The MMRF genomic data can be found on the GDC Data Portal. To request access to protected MMRF data, please apply to dbGaP for access to the MMRF Study (study accession phs000748).

Data from a total of 995 cancer patients with multiple myeloma are available. Genomic data includes DNA sequences from whole genome sequencing (WGS) and whole exome sequencing (WXS), and RNA sequences. Clinical data includes demographics, diagnoses, family histories, molecular tests, and treatments.

The data includes detailed longitudinal information generated as patients were tracked over the course of their disease. 111 of the cases have sequencing data from two or more timepoints. On average, there are 9 timepoints per case and 15 clinical lab values per timepoint.

Cancer Types

Data Types and Access Levels

Data Type Data Format # of Cases and Files # of Follow-up Cases and Files Estimated File Size Data Access Level
Clinical and Biospecimen TSV, JSON 995 Cases 995 Cases N/A Open
WGS Aligned Reads BAM 923 Cases
1933 Files
83 Cases
268 Files
99.61 TB Controlled
WXS Aligned Reads BAM 975 Cases
2067 Files
106 Cases
345 Files
74.66 TB Controlled
WXS Raw Simple Somatic Mutations VCF 959 Cases
5459 Files (5 Callers)
106 Cases
239 Files (5 Callers)
2.96 GB Controlled
WXS Annotated Somatic Mutations VCF 959 Cases
10918 Files (5 Callers)
106 Cases
239 Files (5 Callers)
11.88 GB Controlled
WXS Aggregated Somatic Mutations MAF 959 Cases
1092 Files
106 Cases
239 Files
214.18 MB Controlled
WXS Masked Somatic Mutations MAF 959 Cases
1092 Files
106 Cases
239 Files
41.38 MB Open
RNA-Seq Aligned Reads BAM 787 Cases
859 Files per Alignment Type
58 Cases
130 Files per Alignment Type
32.34 TB Controlled
RNA-Seq Gene Expression Quantification TXT 787 Cases
859 Files per Quantification Type
58 Cases
130 Files per Quantification Type
1.15 GB Open
RNA-Seq Splice Junction Quantification TXT 787 Cases
859 Files
58 Cases
130 Files
2.55 GB Controlled