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Why might variants found in TCGA-generated MAFs be missing from the GDC open access MAF files?

Submitted by Anonymous on

Some of the reasons particular mutations may have been removed include updates to third party databases, more conservative germline-masking rules by the GDC, and different mutation calling pipelines and versions. Despite these differences, the GDC recaptures over 97% of TCGA-validated variants in the controlled-access MAF files. The GDC suggests using controlled-access MAF files if important variants cannot be found in somatic MAF files.

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