Cancer Cell. Volume 31 Issue 3: p411-423, 13 March 2017 10.1016/j.ccell.2017.02.010
We performed genomic, epigenomic, transcriptomic and proteomic characterizations of uterine carcinosarcomas (UCSs). Cohort samples had extensive copy number alterations and highly recurrent somatic mutations. Frequent mutations were found in TP53, PTEN, PIK3CA, PPP2R1A, FBXW7 and KRAS, similar to endometrioid and serous uterine carcinomas. Transcriptome sequencing identified a strong epithelial-to-mesenchymal transition (EMT) gene signature in a subset of cases that was attributable to epigenetic alterations at microRNA promoters. The range of EMT scores in UCS was the largest amongst all tumor types studied via The Cancer Genome Atlas. UCSs shared proteomic features with gynecologic carcinomas and sarcomas with intermediate EMT features. Multiple somatic mutations and copy number alterations in genes that are therapeutic targets were identified.
Data in the GDC
- GDC Manifests
- Open-Access Data - Download Manifest (22 Files)
- Controlled-Access Data - Download Manifest (3 Files)
Supplemental Data
- MAF Files
- Public Mutations - PR_TCGA_UCS_PAIR_Capture_All_Pairs.aggregated.capture.tcga.uuid.curated.somatic.maf
- Additional Public Mutations - UCS.Public_Mutations.tar
- Participant List, Sample List, BAM File List, and Full Listing of TCGA Archives for Data Freeze
- Sample List - UCS.Sample_List.txt
- BAM File Freeze List - UCS_Freeze_04Mar2014.bam.list.txt
- Data Freeze List - UCS.freeze.2016.9.txt
- Peaks - mmc5.xlsx
- Clinical
- XML files containing biospecimen processing and clinical data - UCS.Clinical.tar
- Microsatellite Instability
- Level 1 Microsatellite Instability Data - UCS.Microsatellite_Instability_Level_1.tar
- Public Microsatellite Instability Data - UCS.Microsatellite_Instability.mage-tab.tar
- Reverse Phase Protein Array (RPPA) Expression
- Level 1 Data Archives - UCS.RPPA.Level_1.tar
- Level 2 Data Archives - UCS.RPPA.Level_2.tar
- Level 3 Data Archives - UCS.RPPA.Level_3.tar
- mage-tab Data Archive - UCS.RPPA.mage-tab.tar
- RNA Expression from IlluminaHiseq RNASeq
- Level 3 Data Archives - UCS.RNA_Expression_Level_3.tar
- mage-tab Data Archive - UCS.RNA_Expression_mage-tab.tar
- SNP and Copy Number variation from Affymetrix SNP6
- Level 1 Data Archives - UCS.Genome_Wide_SNP_6.Level_1.tar
- Level 2 Data Archives - UCS.Genome_Wide_SNP_6.Level_2.tar
- Level 3 Data Archives - UCS.Genome_Wide_SNP6_Level_3.tar
- mage-tab Data Archive - UCS.Genome_Wide_SNP6_mage-tab.tar
- miRNA from Illumina HiSeq 2000
- Level 3 Data Archives - UCS.miRNASeqExpression_Level_3.tar
- mage-tab Data Archive - UCS.miRNASeqExpression_mage-tab.tar
- Methylation from Illumina Infinium Human Methylation450
- Level 1 Data Archives - UCS.HumanMethylation450_Level_1.tar
- Level 2 Data Archives - UCS.HumanMethylation450_Level_2.tar
- Level 3 Data Archives - UCS.HumanMethylation450_Level_3.tar
- mage-tab Data Archive - UCS.HumanMethylation450_mage-tab.tar
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Open Access Data
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Controlled Access Data
- Download the appropriate manifest file from the publication page
- Download a token from the GDC Data Portal
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