Clinical Data Elements

Term Category Definition Accepted Values/Type CDE (Collection) Required / Preferred / Optional
Age At Diagnosis Diagnosis The numerical response indicating the age of a person, expressed in years, when they were diagnosed with a disease or disorder. number (units: years) 4828691 (caDSR) Optional
Alcohol History Exposure A response to a question that asks whether the participant has consumed at least 12 drinks of any kind of alcoholic beverage in their lifetime. 'Don't Know/Not Sure', 'No', 'Yes' 2201918 (caDSR) Optional
Alcohol Intensity Exposure Category to describe the patient's current level of alcohol use as self-reported by the patient. 'None', 'Not Evaluated', 'Daily Drinker', 'Occasional Drinker', 'Social Drinker', 'Weekly Drinker' 3457767 (caDSR) Optional
BMI Exposure The body mass divided by the square of the body height expressed in units of kg/m2. number (units: kilograms per square meter) 4973892 (caDSR) Optional
Cigarettes Per Day Exposure The average number of cigarettes smoked per day. number (units: cigarettes) 2001716 (caDSR) Optional
Classification Of Tumor Diagnosis The point in clinical disease progression at which a tumor sample was taken. 'Primary', 'Metastasis', 'Recurrence', 'Other' 808b7f0 (GDC) Required
Days To Birth Diagnosis Time interval from a person's date of birth to the date of initial pathologic diagnosis, represented as a calculated number of days. number (units: days) 3008233 (caDSR/TCGA) Preferred
Days To Last Followup Diagnosis Time interval from the date of last followup to the date of initial pathologic diagnosis, represented as a calculated number of days. number (units: days) 3008273 (caDSR) Required
Days To Last Known Disease Status Diagnosis Time interval from the date of last followup to the date of initial pathologic diagnosis, represented as a calculated number of days. number (units: days) 3008273 (caBIG) Required
Days To Recurrence Diagnosis Time interval from the date of disease recurrence to the date of initial pathologic diagnosis, represented as a calculated number of days. number (units: days) 3008295 (caDSR) Required
Days To Treatment Treatment Number of days from date of initial pathologic diagnosis that treatment began. number (units: days) 56294eaf (GDC) Optional
Ethnicity Demographic Classification based on social groupings that are characterized by a distinctive social and cultural tradition maintained from generation to generation, a common history and origin and a sense of identification with the group; members of the group have distinctive features in their way of life, shared experiences and often a common genetic heritage; these features may be reflected in their experience of health and disease. 'hispanic or latino', 'not hispanic or latino', 'not reported', 'not allowed to collect' 2192213 (caDSR) Required
Gender Demographic Text designations that identify gender. Gender is described as the assemblage of properties that distinguish people on the basis of their societal roles. 'Female', 'Male', 'Unknown', 'Unspecified' 2200604 (caDSR) Required
Height Exposure The height of the patient in centimeters. number (units: centimeters) 649 (caDSR) Optional
Last Known Disease Status Diagnosis The state or condition of an individual's neoplasm at a particular point in time. 'Biochemical evidence of disease without structural correlate', 'Distant met recurrence/progression', 'Loco-regional recurrence/progression', 'Tumor free', 'Unknown tumor status', 'With tumor' 2759550 (caDSR) Required
Morphology Diagnosis The third edition of the International Classification of Diseases for Oncology, published in 2000, used principally in tumor and cancer registries for coding the site (topography) and the histology (morphology) of neoplasms._The study of the structure of the cells and their arrangement to constitute tissues and, finally, the association among these to form organs. In pathology, the microscopic process of identifying normal and abnormal morphologic characteristics in tissues, by employing various cytochemical and immunocytochemical stains._A system of numbered categories for representation of data. string (Codes as provided at ICD-O-3 Online) 3226275 (caDSR) Required
Primary Diagnosis Diagnosis The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation. The term primary indicates that this is the intial diagnosis made or provided in the context of the associated study. string (IDC-10 code) C15220 (NCIt) Required
Prior Malignancy Diagnosis Text term to describe the patient's history of prior cancer diagnosis and the spatial location of any previous cancer occurrence. GDC: allow yes/no/unknown as accepted values. 'Yes', 'No', 'Unknown' 3382736 (caDSR) Optional
Progression Or Recurrence Diagnosis Text indicator to represent the worsening or progression, recurrence of the cancer condition under investigation since the time of last contact with the subject. ''Yes'', ''No'', 'Unevaluable', 'Unknown' 3830556 (caDSR) Required
Race Demographic An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution. 'white', 'american indian or alaska native', 'black or african american', 'asian', 'native hawaiian or other pacific islander', 'other', 'not reported', 'not allowed to collect' C17049 (NCIt) Required
Relationship Age At Diagnosis Family History (Applied to the case's relative) The numerical response indicating the age of a person, expressed in years, when they were diagnosed with a disease or disorder. number (units: years) 4828691 (caDSR) Optional
Relationship Gender Family History (As applied to the case's relative) Text designations that identify gender. Gender is described as the assemblage of properties that distinguish people on the basis of their societal roles. 'Female', 'Male', 'Unknown', 'Unspecified' 2200604 (caDSR) Optional
Relationship Type Family History The subgroup that describes the state of connectedness between members of the unit of society organized around kinship ties. 'Parent', 'Mother', 'Father', 'Child', 'Son', 'Daughter', 'Sibling', 'Brother', 'Sister', 'None', 'Don't Know' 2690165 (caDSR) Optional
Relative With Cancer History Family History Indicator to signify whether or not an individual's biological relative has been diagnosed with another type of cancer. (GDC definition: Indicator to signify whether or not an individual's biological relative has been diagnosed with any type of cancer.) 'Yes', 'No', 'Unknown' 3901752 (caDSR) Optional
Site Of Resection Or Biopsy Diagnosis Term to represent the name of the organ resected that was contiguous to the primary disease site. GDC: Also includes liquid biopsy material. string (Codes as provided at ICD-O-3 Online) 3162811 (caDSR) Preferred
Smoking History Exposure Category describing current smoking status and smoking history as self-reported by a patient. 'Lifelong Non-Smoker', 'Current Smoker', 'Current Reformed Smoker for > 15 yrs', 'Current Refomed Smoker for < or = 15 yrs', 'Current Reformed Smoker Duration Not Specified' 2181650 (caDSR) Optional
Smoking Intensity Exposure Numeric computed value to represent lifetime tobacco exposure defined as number of cigarettes smoked per day x number of years smoked divided by 20. number (units: pack-years) 2955385 (caDSR) Optional
Therapeutic Agent Treatment Any natural, endogenously-derived, synthetic or semi-synthetic compound with pharmacologic activity. A pharmacologic substance has one or more specific mechanism of action(s) through which it exerts one or more effect(s) on the human or animal body. They can be used to potentially prevent, diagnose, treat or relieve symptoms of a disease. Formulation specific agents and some combination agents are also classified as pharmacologic substances. string (String value is the agent name as found in NCI Thesaurus, which indexes approved drugs via RxNorm as well as all experimental drugs.) C1909 (NCIt) Optional
Tissue Or Organ Of Origin Diagnosis The third edition of the International Classification of Diseases for Oncology, published in 2000, used principally in tumor and cancer registries for coding the site (topography) and the histology (morphology) of neoplasms._The description of an anatomical region or of a body part._Named locations of, or within, the body._A system of numbered categories for representation of data. string (Codes as provided at ICD-O-3 Online) 3226281 (caDSR) Required
Treatment Intent Type Treatment Text term to identify the reason for the administration of a treatment regimen. 'Adjuvant', 'Cancer control', 'Cure', 'Initial', 'Other', 'Palliative', 'Prevention', 'Primary', 'Progression', 'Progression after initial', 'Recurrence' 2793511 (caDSR) Optional
Treatment Or Therapy Treatment A yes/no/unknown/not applicable indicator related to the administration of therapeutic agents received before the body specimen was collected. ''Yes'', ''No'', 'Not Applicable', 'Unknown' 4231463 (caDSR) Optional
Tumor Grade Diagnosis The degree of abnormality of cancer cells, a measure of differentiation, the extent to which cancer cells are similar in appearance and function to healthy cells of the same tissue type. The degree of differentiation often relates to the clinical behavior of the particular tumor. Based on the microscopic findings, tumor grade is commonly described by one of four degrees of severity. Histopathologic grade of a tumor may be used to plan treatment and estimate the future course, outcome, and overall prognosis of disease. Certain types of cancers, such as soft tissue sarcoma, primary brain tumors, lymphomas, and breast have special grading systems. string (The accepted values for tumor_grade depend on the tumor site, type, and accepted grading system. These items should accompany the tumor_grade value as associated metadata.) C18000 (NCIt) Required
Tumor Stage Diagnosis The extent of a cancer in the body. Staging is usually based on the size of the tumor, whether lymph nodes contain cancer, and whether the cancer has spread from the original site to other parts of the body. string (The accepted values for tumor_stage depend on the tumor site, type, and accepted staging system. These items should accompany the tumor_stage value as associated metadata.) C16899 (NCIt) Required
Vital Status Diagnosis The state or condition of being living or deceased; also includes the case where the vital status is unknown. 'alive', 'dead', 'lost to follow-up', 'unknown' C25717 (NCIt) Required
Weight Exposure The weight of the patient measured in kilograms. number (units: kilograms) 651 (caDSR) Optional
Year Of Birth Demographic Numeric value to represent the calendar year in which an individual was born. number (units: year) 2896954 (caDSR) Required
Year Of Death Demographic Numeric value to represent the year of the death of an individual. number (units: year) 2897030 (caDSR) Preferred
Years Smoked Exposure Numeric value (or unknown) to represent the number of years a person has been smoking. number (units: years) 3137957 (caDSR) Required